PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth

p53 acetylation is indispensable for its transcriptional activity and tumor suppressive function. However, the identity of reader protein(s) for p53 acetylation remains elusive. PBRM1, the second most highly mutated tumor suppressor gene in kidney cancer, encodes PBRM1. Here, we identify PBRM1 as a...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Cai, Weijia, Su, Liya, Liao, Lili, Liu, Zongzhi Z., Langbein, Lauren, Dulaimi, Essel, Testa, Joseph R., Uzzo, Robert G., Zhong, Zhijiu, Jiang, Wei, Yan, Qin, Zhang, Qing, Yang, Haifeng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6925188/
https://ncbi.nlm.nih.gov/pubmed/31863007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13608-1
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