Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer

Whereas VHL inactivation is a primary event in clear cell renal cell carcinoma (ccRCC), the precise mechanism(s) of how this interacts with the secondary mutations in tumor suppressor genes, including PBRM1, KDM5C/JARID1C, SETD2, and/or BAP1, remains unclear. Gene expression analyses reveal that VHL...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Liao, Lili, Liu, Zongzhi Z, Langbein, Lauren, Cai, Weijia, Cho, Eun-Ah, Na, Jie, Niu, Xiaohua, Jiang, Wei, Zhong, Zhijiu, Cai, Wesley L, Jagannathan, Geetha, Dulaimi, Essel, Testa, Joseph R, Uzzo, Robert G, Wang, Yuxin, Stark, George R, Sun, Jianxin, Peiper, Stephen, Xu, Yaomin, Yan, Qin, Yang, Haifeng
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234029/
https://ncbi.nlm.nih.gov/pubmed/30355451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.37925
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