Immunohistochemistry Successfully Uncovers Intratumoral Heterogeneity and Widespread Co-Losses of Chromatin Regulators in Clear Cell Renal Cell Carcinoma

Recent studies have shown that intratumoral heterogeneity (ITH) is prevalent in clear cell renal cell carcinoma (ccRCC), based on DNA sequencing and chromosome aberration analysis of multiple regions from the same tumor. VHL mutations were found to be universal throughout individual tumors when it o...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Jiang, Wei, Dulaimi, Essel, Devarajan, Karthik, Parsons, Theodore, Wang, Qiong, Liao, Lili, Cho, Eun-Ah, O'Neill, Raymond, Solomides, Charalambos, Peiper, Stephen C., Testa, Joseph R., Uzzo, Robert, Yang, Haifeng
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5072613/
https://ncbi.nlm.nih.gov/pubmed/27764136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164554
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