Immunohistochemistry Successfully Uncovers Intratumoral Heterogeneity and Widespread Co-Losses of Chromatin Regulators in Clear Cell Renal Cell Carcinoma

Recent studies have shown that intratumoral heterogeneity (ITH) is prevalent in clear cell renal cell carcinoma (ccRCC), based on DNA sequencing and chromosome aberration analysis of multiple regions from the same tumor. VHL mutations were found to be universal throughout individual tumors when it o...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Jiang, Wei, Dulaimi, Essel, Devarajan, Karthik, Parsons, Theodore, Wang, Qiong, Liao, Lili, Cho, Eun-Ah, O'Neill, Raymond, Solomides, Charalambos, Peiper, Stephen C., Testa, Joseph R., Uzzo, Robert, Yang, Haifeng
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5072613/
https://ncbi.nlm.nih.gov/pubmed/27764136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164554
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