Immunohistochemistry Successfully Uncovers Intratumoral Heterogeneity and Widespread Co-Losses of Chromatin Regulators in Clear Cell Renal Cell Carcinoma

Recent studies have shown that intratumoral heterogeneity (ITH) is prevalent in clear cell renal cell carcinoma (ccRCC), based on DNA sequencing and chromosome aberration analysis of multiple regions from the same tumor. VHL mutations were found to be universal throughout individual tumors when it o...

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Publicado en:PLoS One
Autores principales: Jiang, Wei, Dulaimi, Essel, Devarajan, Karthik, Parsons, Theodore, Wang, Qiong, Liao, Lili, Cho, Eun-Ah, O'Neill, Raymond, Solomides, Charalambos, Peiper, Stephen C., Testa, Joseph R., Uzzo, Robert, Yang, Haifeng
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5072613/
https://ncbi.nlm.nih.gov/pubmed/27764136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164554
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