Immunohistochemistry Successfully Uncovers Intratumoral Heterogeneity and Widespread Co-Losses of Chromatin Regulators in Clear Cell Renal Cell Carcinoma

Recent studies have shown that intratumoral heterogeneity (ITH) is prevalent in clear cell renal cell carcinoma (ccRCC), based on DNA sequencing and chromosome aberration analysis of multiple regions from the same tumor. VHL mutations were found to be universal throughout individual tumors when it o...

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Veröffentlicht in:PLoS One
Hauptverfasser: Jiang, Wei, Dulaimi, Essel, Devarajan, Karthik, Parsons, Theodore, Wang, Qiong, Liao, Lili, Cho, Eun-Ah, O'Neill, Raymond, Solomides, Charalambos, Peiper, Stephen C., Testa, Joseph R., Uzzo, Robert, Yang, Haifeng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5072613/
https://ncbi.nlm.nih.gov/pubmed/27764136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164554
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