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Lysine succinylation and SIRT5 couple nutritional status to glutamine catabolism
The metabolic microenvironment of tumors is characterized by fluctuating and limited nutrient availability. To survive these conditions, cancer cell-intrinsic mechanisms sense and signal nutritional status. We describe how glutaminase (GLS) is destabilized by lysine succinylation and stabilized by t...
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| Publicado en: | Mol Cell Oncol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Taylor & Francis
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7199738/ https://ncbi.nlm.nih.gov/pubmed/32391426 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2020.1735284 |
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