SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis

The mitochondrial enzyme glutaminase (GLS) is frequently up-regulated during tumorigenesis and is being evaluated as a target for cancer therapy. GLS catalyzes the hydrolysis of glutamine to glutamate, which then supplies diverse metabolic pathways with carbon and/or nitrogen. Here, we report that S...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Greene, Kai Su, Lukey, Michael J., Wang, Xueying, Blank, Bryant, Druso, Joseph E., Lin, Miao-chong J., Stalnecker, Clint A., Zhang, Chengliang, Negrón Abril, Yashira, Erickson, Jon W., Wilson, Kristin F., Lin, Hening, Weiss, Robert S., Cerione, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936584/
https://ncbi.nlm.nih.gov/pubmed/31843902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1911954116
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