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The activation loop and substrate-binding cleft of glutaminase C are allosterically coupled
The glutaminase C (GAC) isoform of mitochondrial glutaminase is overexpressed in many cancer cells and therefore represents a potential therapeutic target. Understanding the regulation of GAC activity has been guided by the development of spectroscopic approaches that measure glutaminase activity in...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6996896/ https://ncbi.nlm.nih.gov/pubmed/31871054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010314 |
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