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Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells
The mitochondrial enzyme glutaminase C (GAC) catalyzes the hydrolysis of glutamine to glutamate plus ammonia, a key step in the metabolism of glutamine by cancer cells. Recently, we discovered a class of allosteric inhibitors of GAC that inhibit cancer cell growth without affecting their normal cell...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4299208/ https://ncbi.nlm.nih.gov/pubmed/25548170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414056112 |
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