Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells

The mitochondrial enzyme glutaminase C (GAC) catalyzes the hydrolysis of glutamine to glutamate plus ammonia, a key step in the metabolism of glutamine by cancer cells. Recently, we discovered a class of allosteric inhibitors of GAC that inhibit cancer cell growth without affecting their normal cell...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Stalnecker, Clint A., Ulrich, Scott M., Li, Yunxing, Ramachandran, Sekar, McBrayer, Mary Kate, DeBerardinis, Ralph J., Cerione, Richard A., Erickson, Jon W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4299208/
https://ncbi.nlm.nih.gov/pubmed/25548170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414056112
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