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Enhanced genome editing in human iPSCs with CRISPR-CAS9 by co-targeting ATP1a1

Genome editing in human induced pluripotent stem cells (iPSCs) provides the potential for disease modeling and cell therapy. By generating iPSCs with specific mutations, researchers can differentiate the modified cells to their lineage of interest for further investigation. However, the low efficien...

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Pubblicato in:PeerJ
Autori principali: Liu, Jui-Tung, Corbett, James L., Heslop, James A., Duncan, Stephen A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: PeerJ Inc. 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7197401/
https://ncbi.nlm.nih.gov/pubmed/32391204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.9060
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