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Pathogenic variants in CDC45 on the remaining allele in patients with a chromosome 22q11.2 deletion result in a novel autosomal recessive condition

PURPOSE: The 22q11.2 deletion syndrome (22q11.2DS) is the most common microdeletion in humans, with highly variable phenotypic expression. Whereas congenital heart defects, palatal anomalies, immunodeficiency, hypoparathyroidism, and neuropsychiatric conditions are observed in over 50% of patients w...

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發表在:Genet Med
Main Authors: Unolt, Marta, Kammoun, Molka, Nowakowska, Beata, Graham, Gail E., Crowley, T. Blaine, Hestand, Matthew S., Demaerel, Wolfram, Geremek, Maciej, Emanuel, Beverly S., Zackai, Elaine H., Vermeesch, Joris R., McDonald-McGinn, Donna
格式: Artigo
語言:Inglês
出版: Nature Publishing Group US 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7197230/
https://ncbi.nlm.nih.gov/pubmed/31474763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41436-019-0645-4
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