Prevalent and diverse intratumoral oncoprotein-specific CD8(+) T cells within polyoma virus–driven Merkel cell carcinomas

Merkel cell carcinoma (MCC) is often caused by persistent expression of Merkel cell polyomavirus (MCPyV) T-antigen (T-Ag). These non-self proteins comprise about 400 amino acids (AAs). Clinical responses to immune checkpoint inhibitors, seen in about half of patients, may relate to T-Ag–specific T c...

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Veröffentlicht in:Cancer Immunol Res
Hauptverfasser: Jing, Lichen, Ott, Mariliis, Church, Candice D., Kulikauskas, Rima M., Ibrani, Dafina, Iyer, Jayasri G., Afanasiev, Olga K., Colunga, Aric, Cook, Maclean M., Xie, Hong, Greninger, Alexander L., Paulson, Kelly G., Chapuis, Aude G., Bhatia, Shailender, Nghiem, Paul, Koelle, David M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7196523/
https://ncbi.nlm.nih.gov/pubmed/32179557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-19-0647
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