Intratumoral G100, a TLR4 agonist, induces anti-tumor immune responses and tumor regression in patients with Merkel cell carcinoma

PURPOSE: G100 is a toll-like receptor 4 (TLR4) agonist that triggers innate and adaptive anti-tumor immune responses in preclinical models. This pilot study assessed the safety, efficacy, and immunologic activity of intratumoral (IT) administration of G100 in patients with Merkel cell carcinoma (MCC...

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Publicado en:Clin Cancer Res
Main Authors: Bhatia, Shailender, Miller, Natalie J., Lu, Hailing, Vandeven, Natalie, Ibrani, Dafina, Shinohara, Michi M., Byrd, David R., Parvathaneni, Upendra, Kulikauskas, Rima, Meulen, Janter, Hsu, Frank J., Koelle, David M., Nghiem, Paul
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6368904/
https://ncbi.nlm.nih.gov/pubmed/30093453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0469
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