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Rationale for immune-based therapies in Merkel polyomavirus-positive and -negative Merkel cell carcinomas

Merkel cell carcinoma (MCC) is a rare but often deadly skin cancer that is typically caused by the Merkel cell polyomavirus (MCPyV). Polyomavirus T-antigen oncoproteins are persistently expressed in virus-positive MCCs (˜80% of cases), while remarkably high numbers of tumor-associated neoantigens ar...

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Detalhes bibliográficos
Publicado no:Immunotherapy
Main Authors: Vandeven, Natalie, Nghiem, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: Future Medicine Ltd 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5827814/
https://ncbi.nlm.nih.gov/pubmed/27381685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/imt-2016-0009
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