HER2-mediated internalization of cytotoxic agents in ERBB2 amplified or mutant lung cancers

Amplification and oncogenic mutations of ERBB2, the gene encoding the HER2 receptor tyrosine kinase, promote receptor hyperactivation and tumor growth. Here we demonstrate that HER2 ubiquitination and internalization, rather than its overexpression, are key mechanisms underlying endocytosis and cons...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Cancer Discov
المؤلفون الرئيسيون: Li, Bob T., Michelini, Flavia, Misale, Sandra, Cocco, Emiliano, Baldino, Laura, Cai, Yanyan, Shifman, Sophie, Tu, Hai-Yan, Myers, Mackenzie L., Xu, Chongrui, Mattar, Marissa, Khodos, Inna, Little, Megan, Qeriqi, Besnik, Weitsman, Gregory, Wilhem, Clare J., Lalani, Alshad S., Diala, Irmina, Freedman, Rachel A., Lin, Nancy U., Solit, David B., Berger, Michael F., Barber, Paul R., Ng, Tony, Offin, Michael, Isbell, James M., Jones, David R., Yu, Helena A., Thyparambil, Sheeno, Liao, Wei-Li, Bhalkikar, Anuja, Cecchi, Fabiola, Hyman, David M., Lewis, Jason S., Buonocore, Darren J., Ho, Alan L., Makker, Vicky, Reis-Filho, Jorge S., Razavi, Pedram, Arcila, Maria E., Kris, Mark G., Poirier, John T., Shen, Ronglai, Tsurutani, Junji, Ulaner, Gary A., de Stanchina, Elisa, Rosen, Neal, Rudin, Charles M., Scaltriti, Maurizio
التنسيق: Artigo
اللغة:Inglês
منشور في: 2020
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC7196485/
https://ncbi.nlm.nih.gov/pubmed/32213539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-20-0215
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