HER2-mediated internalization of cytotoxic agents in ERBB2 amplified or mutant lung cancers

Amplification and oncogenic mutations of ERBB2, the gene encoding the HER2 receptor tyrosine kinase, promote receptor hyperactivation and tumor growth. Here we demonstrate that HER2 ubiquitination and internalization, rather than its overexpression, are key mechanisms underlying endocytosis and cons...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Li, Bob T., Michelini, Flavia, Misale, Sandra, Cocco, Emiliano, Baldino, Laura, Cai, Yanyan, Shifman, Sophie, Tu, Hai-Yan, Myers, Mackenzie L., Xu, Chongrui, Mattar, Marissa, Khodos, Inna, Little, Megan, Qeriqi, Besnik, Weitsman, Gregory, Wilhem, Clare J., Lalani, Alshad S., Diala, Irmina, Freedman, Rachel A., Lin, Nancy U., Solit, David B., Berger, Michael F., Barber, Paul R., Ng, Tony, Offin, Michael, Isbell, James M., Jones, David R., Yu, Helena A., Thyparambil, Sheeno, Liao, Wei-Li, Bhalkikar, Anuja, Cecchi, Fabiola, Hyman, David M., Lewis, Jason S., Buonocore, Darren J., Ho, Alan L., Makker, Vicky, Reis-Filho, Jorge S., Razavi, Pedram, Arcila, Maria E., Kris, Mark G., Poirier, John T., Shen, Ronglai, Tsurutani, Junji, Ulaner, Gary A., de Stanchina, Elisa, Rosen, Neal, Rudin, Charles M., Scaltriti, Maurizio
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7196485/
https://ncbi.nlm.nih.gov/pubmed/32213539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-20-0215
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