HER2-mediated internalization of cytotoxic agents in ERBB2 amplified or mutant lung cancers

Amplification and oncogenic mutations of ERBB2, the gene encoding the HER2 receptor tyrosine kinase, promote receptor hyperactivation and tumor growth. Here we demonstrate that HER2 ubiquitination and internalization, rather than its overexpression, are key mechanisms underlying endocytosis and cons...

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Detaylı Bibliyografya
Yayımlandı:Cancer Discov
Asıl Yazarlar: Li, Bob T., Michelini, Flavia, Misale, Sandra, Cocco, Emiliano, Baldino, Laura, Cai, Yanyan, Shifman, Sophie, Tu, Hai-Yan, Myers, Mackenzie L., Xu, Chongrui, Mattar, Marissa, Khodos, Inna, Little, Megan, Qeriqi, Besnik, Weitsman, Gregory, Wilhem, Clare J., Lalani, Alshad S., Diala, Irmina, Freedman, Rachel A., Lin, Nancy U., Solit, David B., Berger, Michael F., Barber, Paul R., Ng, Tony, Offin, Michael, Isbell, James M., Jones, David R., Yu, Helena A., Thyparambil, Sheeno, Liao, Wei-Li, Bhalkikar, Anuja, Cecchi, Fabiola, Hyman, David M., Lewis, Jason S., Buonocore, Darren J., Ho, Alan L., Makker, Vicky, Reis-Filho, Jorge S., Razavi, Pedram, Arcila, Maria E., Kris, Mark G., Poirier, John T., Shen, Ronglai, Tsurutani, Junji, Ulaner, Gary A., de Stanchina, Elisa, Rosen, Neal, Rudin, Charles M., Scaltriti, Maurizio
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7196485/
https://ncbi.nlm.nih.gov/pubmed/32213539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-20-0215
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