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Single-cell expression and Mendelian randomization analyses identify blood genes associated with lifespan and chronic diseases

The human lifespan is a heritable trait, which is intricately linked to the development of disorders. Here, we show that genetic associations for the parental lifespan are enriched in open chromatin of blood cells. By using blood expression quantitative trait loci (eQTL) derived from 31,684 samples,...

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Detalhes bibliográficos
Publicado no:Commun Biol
Main Authors: Chignon, Arnaud, Bon-Baret, Valentin, Boulanger, Marie-Chloé, Li, Zhonglin, Argaud, Deborah, Bossé, Yohan, Thériault, Sébastien, Arsenault, Benoit J., Mathieu, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7195437/
https://ncbi.nlm.nih.gov/pubmed/32358504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-0937-x
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