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Single-cell expression and Mendelian randomization analyses identify blood genes associated with lifespan and chronic diseases
The human lifespan is a heritable trait, which is intricately linked to the development of disorders. Here, we show that genetic associations for the parental lifespan are enriched in open chromatin of blood cells. By using blood expression quantitative trait loci (eQTL) derived from 31,684 samples,...
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| Veröffentlicht in: | Commun Biol |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7195437/ https://ncbi.nlm.nih.gov/pubmed/32358504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-0937-x |
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