Non-catalytic ubiquitin binding by A20 prevents psoriatic arthritis-like disease and inflammation

A20 is an anti-inflammatory protein that is strongly linked to human disease. Here we find that mice expressing three distinct targeted mutations of A20’s ZF7 ubiquitin binding motif uniformly developed digit arthritis that shares features with psoriatic arthritis, while mice expressing point mutati...

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Bibliographic Details
Published in:Nat Immunol
Main Authors: Razani, Bahram, Whang, Michael I., Kim, Francis S., Nakamura, Mary C., Sun, Xiaofei, Advincula, Rommel, Turnbaugh, Jessie A., Pendse, Mihir, Tanbun, Priscilia, Achacoso, Philip, Turnbaugh, Peter J., Malynn, Barbara A., Ma, Averil
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7195210/
https://ncbi.nlm.nih.gov/pubmed/32205880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-020-0634-4
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