A20 restricts ubiquitination of pro-interleukin-1β protein complexes and suppresses NLRP3 inflammasome activity

Inappropriate inflammasome activation contributes to multiple human diseases, but the mechanisms by which inflammasomes are suppressed are poorly understood. The NFκB inhibitor A20 is a ubiquitin-modifying enzyme that may prevent human inflammatory diseases and lymphomas. Here, we report that A20-de...

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Foilsithe in:Immunity
Main Authors: Duong, Bao H., Onizawa, Michio, Oses-Prieto, Juan A., Advincula, Rommel, Burlingame, Alma, Malynn, Barbara A., Ma, Averil
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4302274/
https://ncbi.nlm.nih.gov/pubmed/25607459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.12.031
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