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Non-catalytic ubiquitin binding by A20 prevents psoriatic arthritis-like disease and inflammation
A20 is an anti-inflammatory protein that is strongly linked to human disease. Here we find that mice expressing three distinct targeted mutations of A20’s ZF7 ubiquitin binding motif uniformly developed digit arthritis that shares features with psoriatic arthritis, while mice expressing point mutati...
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| 出版年: | Nat Immunol |
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| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7195210/ https://ncbi.nlm.nih.gov/pubmed/32205880 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-020-0634-4 |
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