The mTORC2-Akt1 Cascade Is Crucial for c-Myc to Promote Hepatocarcinogenesis in Mice and Humans

Hepatocellular carcinoma (HCC) is a deadly form of liver cancer with limited treatment options. The c-Myc transcription factor is a pivotal player in hepatocarcinogenesis, but the mechanisms underlying c-Myc oncogenic activity in the liver remain poorly delineated. Mammalian target of rapamycin comp...

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Udgivet i:Hepatology
Main Authors: Xu, Zhong, Xu, Meng, Liu, Pin, Zhang, Shu, Shang, Runze, Qiao, Yu, Che, Li, Ribback, Silvia, Cigliano, Antonio, Evert, Katja, Pascale, Rosa M., Dombrowski, Frank, Evert, Matthias, Chen, Xi, Calvisi, Diego F., Chen, Xin
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7195156/
https://ncbi.nlm.nih.gov/pubmed/31062368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30697
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