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Importance of γ-secretase in the regulation of liver X receptor and cellular lipid metabolism
Presenilins (PS) are the catalytic components of γ-secretase complexes that mediate intramembrane proteolysis. Mutations in the PS genes are a major cause of familial early-onset Alzheimer disease and affect the cleavage of the amyloid precursor protein, thereby altering the production of the amyloi...
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| Publicado no: | Life Sci Alliance |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Life Science Alliance LLC
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7195048/ https://ncbi.nlm.nih.gov/pubmed/32354700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900521 |
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