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Effect of linker on the binding free energy of stapled p53/HDM2 complex
Inactivation of the tumor suppressor p53 resulting from the binding with a negative regulator HDM2 is among the predominant defects in human cancers. p53-mimicking peptides whose conformational and proteolytic stability is enhanced by an all-hydrocarbon staple are being recognized as promising antic...
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| Publicado no: | PLoS One |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7192472/ https://ncbi.nlm.nih.gov/pubmed/32353067 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0232613 |
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