Placental transfer of Letermovir & Maribavir in the ex vivo human cotyledon perfusion model. New perspectives for in utero treatment of congenital cytomegalovirus infection

BACKGROUND: Congenital cytomegalovirus infection can lead to severe sequelae. When fetal infection is confirmed, we hypothesize that fetal treatment could improve the outcome. Maternal oral administration of an effective drug crossing the placenta could allow fetal treatment. Letermovir (LMV) and Ma...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Faure Bardon, Valentine, Peytavin, Gilles, Lê, Minh Patrick, Guilleminot, Tiffany, Elefant, Elisabeth, Stirnemann, Julien, Leruez-Ville, Marianne, Ville, Yves
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7192425/
https://ncbi.nlm.nih.gov/pubmed/32353010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0232140
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