Two mutations commonly associated with daptomycin resistance in Enterococcus faecium LiaS(T120A) and LiaR(W73C) appear to function epistatically in LiaFSR signaling

The cyclic antimicrobial lipopeptide daptomycin is now frequently used as a first-line therapy in serious infections caused by multidrug-resistant Enterococcus faecium. Resistance to daptomycin in E. faecium is mediated by activation of the LiaFSR membrane stress response pathway. Deletion of liaR,...

Full description

Saved in:
Bibliographic Details
Published in:Biochemistry
Main Authors: Davlieva, Milya, Wu, Chelsea, Zhou, Yue, Arias, Cesar A., Shamoo, Yousif
Format: Artigo
Language:Inglês
Published: 2018
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7192238/
https://ncbi.nlm.nih.gov/pubmed/30403130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b01072
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items