Daptomycin Resistance in Enterococcus faecium Can Be Delayed by Disruption of the LiaFSR Stress Response Pathway

LiaFSR signaling plays a major role in mediating daptomycin (DAP) resistance in enterococci, and the lack of a functional LiaFSR pathway leads to DAP hypersusceptibility. Using in vitro experimental evolution, we evaluated how Enterococcus faecium with a liaR response regulator gene deletion evolved...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Prater, Amy G., Mehta, Heer H., Beabout, Kathryn, Supandy, Adeline, Miller, William R., Tran, Truc T., Arias, Cesar A., Shamoo, Yousif
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097453/
https://ncbi.nlm.nih.gov/pubmed/33468468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01317-20
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