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Two mutations commonly associated with daptomycin resistance in Enterococcus faecium LiaS(T120A) and LiaR(W73C) appear to function epistatically in LiaFSR signaling
The cyclic antimicrobial lipopeptide daptomycin is now frequently used as a first-line therapy in serious infections caused by multidrug-resistant Enterococcus faecium. Resistance to daptomycin in E. faecium is mediated by activation of the LiaFSR membrane stress response pathway. Deletion of liaR,...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7192238/ https://ncbi.nlm.nih.gov/pubmed/30403130 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b01072 |
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