Age-related loss of innate immune antimicrobial function of dermal fat is mediated by transforming growth factor beta

Dermal fibroblasts (dFB) resist infection by locally differentiating into adipocytes and producing the antimicrobial peptide cathelicidin in response to S. aureus. Here we showed that neonatal skin was enriched with adipogenic dFB and immature dermal fat that highly expressed cathelicidin.. The pool...

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發表在:Immunity
Main Authors: Zhang, Ling-juan, Chen, Stella Xiang, Guerrero-Juarez, Christian F., Li, Fengwu, Tong, Yun, Liang, Yuqiong, Liggins, Marc, Chen, Xu, Chen, Hao, Li, Min, Hata, Tissa, Zheng, Ye, Plikus, Maksim V., Gallo, Richard L.
格式: Artigo
語言:Inglês
出版: 2018
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7191997/
https://ncbi.nlm.nih.gov/pubmed/30594464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.11.003
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