Age-related loss of innate immune antimicrobial function of dermal fat is mediated by transforming growth factor beta

Dermal fibroblasts (dFB) resist infection by locally differentiating into adipocytes and producing the antimicrobial peptide cathelicidin in response to S. aureus. Here we showed that neonatal skin was enriched with adipogenic dFB and immature dermal fat that highly expressed cathelicidin.. The pool...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Immunity
Asıl Yazarlar: Zhang, Ling-juan, Chen, Stella Xiang, Guerrero-Juarez, Christian F., Li, Fengwu, Tong, Yun, Liang, Yuqiong, Liggins, Marc, Chen, Xu, Chen, Hao, Li, Min, Hata, Tissa, Zheng, Ye, Plikus, Maksim V., Gallo, Richard L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7191997/
https://ncbi.nlm.nih.gov/pubmed/30594464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.11.003
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