Age-related loss of innate immune antimicrobial function of dermal fat is mediated by transforming growth factor beta

Dermal fibroblasts (dFB) resist infection by locally differentiating into adipocytes and producing the antimicrobial peptide cathelicidin in response to S. aureus. Here we showed that neonatal skin was enriched with adipogenic dFB and immature dermal fat that highly expressed cathelicidin.. The pool...

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Dettagli Bibliografici
Pubblicato in:Immunity
Autori principali: Zhang, Ling-juan, Chen, Stella Xiang, Guerrero-Juarez, Christian F., Li, Fengwu, Tong, Yun, Liang, Yuqiong, Liggins, Marc, Chen, Xu, Chen, Hao, Li, Min, Hata, Tissa, Zheng, Ye, Plikus, Maksim V., Gallo, Richard L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7191997/
https://ncbi.nlm.nih.gov/pubmed/30594464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.11.003
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