Myeloid-specific Asxl2 deletion limits diet-induced obesity by regulating energy expenditure

We previously established that global deletion of the enhancer of trithorax and polycomb (ETP) gene, Asxl2, prevents weight gain. Because proinflammatory macrophages recruited to adipose tissue are central to the metabolic complications of obesity, we explored the role of ASXL2 in myeloid lineage ce...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Zou, Wei, Rohatgi, Nidhi, Brestoff, Jonathan R., Moley, John R., Li, Yongjia, Williams, Jesse W., Alippe, Yael, Pan, Hua, Pietka, Terri A., Mbalaviele, Gabriel, Newberry, Elizabeth P., Davidson, Nicholas O., Dey, Anwesha, Shoghi, Kooresh I., Head, Richard D., Wickline, Samuel A., Randolph, Gwendalyn J., Abumrad, Nada A., Teitelbaum, Steven L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190927/
https://ncbi.nlm.nih.gov/pubmed/32310225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI128687
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