ASXL1 impairs osteoclast formation by epigenetic regulation of NFATc1

Additional sex comb-like 1 (ASXL1) mutations are commonly associated with myeloid malignancies and are markers of aggressive disease. The fact that ASXL1 is necessary for myeloid differentiation raises the possibility it also regulates osteoclasts. We find deletion of ASXL1 in myeloid cells results...

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Bibliografische gegevens
Gepubliceerd in:Blood Adv
Hoofdauteurs: Rohatgi, Nidhi, Zou, Wei, Collins, Patrick L., Brestoff, Jonathan R., Chen, Timothy H., Abu-Amer, Yousef, Teitelbaum, Steven L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2018
Onderwerpen:
Hematopoiesis and Stem Cells
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177649/
https://ncbi.nlm.nih.gov/pubmed/30266822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018018309
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