Myeloid-specific Asxl2 deletion limits diet-induced obesity by regulating energy expenditure

We previously established that global deletion of the enhancer of trithorax and polycomb (ETP) gene, Asxl2, prevents weight gain. Because proinflammatory macrophages recruited to adipose tissue are central to the metabolic complications of obesity, we explored the role of ASXL2 in myeloid lineage ce...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Zou, Wei, Rohatgi, Nidhi, Brestoff, Jonathan R., Moley, John R., Li, Yongjia, Williams, Jesse W., Alippe, Yael, Pan, Hua, Pietka, Terri A., Mbalaviele, Gabriel, Newberry, Elizabeth P., Davidson, Nicholas O., Dey, Anwesha, Shoghi, Kooresh I., Head, Richard D., Wickline, Samuel A., Randolph, Gwendalyn J., Abumrad, Nada A., Teitelbaum, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190927/
https://ncbi.nlm.nih.gov/pubmed/32310225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI128687
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