ACSL4 promotes hepatocellular carcinoma progression via c-Myc stability mediated by ERK/FBW7/c-Myc axis

Hepatocellular carcinoma (HCC) is a highly heterogeneous, multigene-driven malignant tumor. Long chain acyl-CoA synthetase 4 (ACSL4), an enzyme has pivotal roles in arachidonic acid (AA) metabolism. However, its function and the underlying molecular mechanisms in HCC are still not fully elucidated....

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Publicat a:Oncogenesis
Autors principals: Chen, Junru, Ding, Chaofeng, Chen, Yunhao, Hu, Wendi, Lu, Yuejie, Wu, Wenxuan, Zhang, Yanpeng, Yang, Beng, Wu, Hao, Peng, Chuanhui, Xie, Haiyang, Zhou, Lin, Wu, Jian, Zheng, Shusen
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190855/
https://ncbi.nlm.nih.gov/pubmed/32350243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-020-0226-z
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