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Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity

Cytosine base editors (CBEs) enable efficient, programmable reversion of T•A to C•G point mutations in the human genome. Recently, cytosine base editors with rAPOBEC1 were reported to induce unguided cytosine deamination in genomic DNA and cellular RNA. Here we report eight next-generation CBEs (BE4...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Yu, Yi, Leete, Thomas C., Born, David A., Young, Lauren, Barrera, Luis A., Lee, Seung-Joo, Rees, Holly A., Ciaramella, Giuseppe, Gaudelli, Nicole M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2020
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7189382/
https://ncbi.nlm.nih.gov/pubmed/32345976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15887-5
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