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Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity
Cytosine base editors (CBEs) enable efficient, programmable reversion of T•A to C•G point mutations in the human genome. Recently, cytosine base editors with rAPOBEC1 were reported to induce unguided cytosine deamination in genomic DNA and cellular RNA. Here we report eight next-generation CBEs (BE4...
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| Publicado en: | Nat Commun |
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| Autores principales: | , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7189382/ https://ncbi.nlm.nih.gov/pubmed/32345976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15887-5 |
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