Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin

Edema stemming from leaky blood vessels is common in eye diseases such as age-related macular degeneration and diabetic retinopathy. Whereas therapies targeting vascular endothelial growth factor A (VEGFA) can suppress leakage, side-effects include vascular rarefaction and geographic atrophy. By cha...

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Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Smith, Ross O, Ninchoji, Takeshi, Gordon, Emma, André, Helder, Dejana, Elisabetta, Vestweber, Dietmar, Kvanta, Anders, Claesson-Welsh, Lena
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2020
Onderwerpen:
Cell Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7188482/
https://ncbi.nlm.nih.gov/pubmed/32312382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.54056
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