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Stabilizing the VE-cadherin–catenin complex blocks leukocyte extravasation and vascular permeability
To determine whether leukocytes need to open endothelial cell contacts during extravasation, we decided to generate mice with strongly stabilized endothelial junctions. To this end, we replaced VE-cadherin genetically by a VE-cadherin–α-catenin fusion construct. Such mice were completely resistant t...
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| Главные авторы: | , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3199392/ https://ncbi.nlm.nih.gov/pubmed/21857650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.304 |
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