Stabilizing the VE-cadherin–catenin complex blocks leukocyte extravasation and vascular permeability

To determine whether leukocytes need to open endothelial cell contacts during extravasation, we decided to generate mice with strongly stabilized endothelial junctions. To this end, we replaced VE-cadherin genetically by a VE-cadherin–α-catenin fusion construct. Such mice were completely resistant t...

Full description

Saved in:
Bibliographic Details
Main Authors: Schulte, Dörte, Küppers, Verena, Dartsch, Nina, Broermann, Andre, Li, Hang, Zarbock, Alexander, Kamenyeva, Olena, Kiefer, Friedemann, Khandoga, Alexander, Massberg, Steffen, Vestweber, Dietmar
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2011
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199392/
https://ncbi.nlm.nih.gov/pubmed/21857650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.304
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items