Stabilizing the VE-cadherin–catenin complex blocks leukocyte extravasation and vascular permeability

To determine whether leukocytes need to open endothelial cell contacts during extravasation, we decided to generate mice with strongly stabilized endothelial junctions. To this end, we replaced VE-cadherin genetically by a VE-cadherin–α-catenin fusion construct. Such mice were completely resistant t...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Schulte, Dörte, Küppers, Verena, Dartsch, Nina, Broermann, Andre, Li, Hang, Zarbock, Alexander, Kamenyeva, Olena, Kiefer, Friedemann, Khandoga, Alexander, Massberg, Steffen, Vestweber, Dietmar
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199392/
https://ncbi.nlm.nih.gov/pubmed/21857650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.304
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