Stabilizing the VE-cadherin–catenin complex blocks leukocyte extravasation and vascular permeability

To determine whether leukocytes need to open endothelial cell contacts during extravasation, we decided to generate mice with strongly stabilized endothelial junctions. To this end, we replaced VE-cadherin genetically by a VE-cadherin–α-catenin fusion construct. Such mice were completely resistant t...

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Main Authors: Schulte, Dörte, Küppers, Verena, Dartsch, Nina, Broermann, Andre, Li, Hang, Zarbock, Alexander, Kamenyeva, Olena, Kiefer, Friedemann, Khandoga, Alexander, Massberg, Steffen, Vestweber, Dietmar
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199392/
https://ncbi.nlm.nih.gov/pubmed/21857650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.304
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