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eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin
BACKGROUND: Hypoxia and consequent production of vascular endothelial growth factor A (VEGFA) promote blood vessel leakiness and edema in ocular diseases. Anti-VEGFA therapeutics may aggravate hypoxia; therefore, therapy development is needed. METHODS: Oxygen-induced retinopathy was used as a model...
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| 出版年: | eLife |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
eLife Sciences Publications, Ltd
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8087444/ https://ncbi.nlm.nih.gov/pubmed/33908348 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.64944 |
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