Genetic ablation of hematopoietic cell kinase accelerates Alzheimer’s disease-like neuropathology in Tg2576 mice

Microglial dysregulation, pertaining to impairment in phagocytosis, clearance and containment of amyloid-β (Aβ), and activation of neuroinflammation, have been posited to contribute to the pathogenesis of Alzheimer’s disease (AD). Detailed cellular mechanisms that are disrupted during the disease co...

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Veröffentlicht in:Mol Neurobiol
Hauptverfasser: Lim, Siok Lam, Tran, Diana Nguyen, Kieu, Zanett, Chen, Christine, Villanueva, Emmanuel, Ghiaar, Sagar, Gallup, Victoria, Zumkehr, Joannee, Cribbs, David H., Rodriguez-Ortiz, Carlos J., Kitazawa, Masashi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7187907/
https://ncbi.nlm.nih.gov/pubmed/32146679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-020-01894-6
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