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Griffithsin Retains Anti-HIV-1 Potency with Changes in gp120 Glycosylation and Complements Broadly Neutralizing Antibodies PGT121 and PGT126

Griffithsin (Grft) is an antiviral lectin that has been shown to potently inhibit HIV-1 by binding high-mannose N-linked glycosylation sites on HIV-1 gp120. A key factor for Grft potency is glycosylation at N295 of gp120, which is directly adjacent to N332, a target glycan for an entire class of bro...

詳細記述

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書誌詳細
出版年:Antimicrob Agents Chemother
主要な著者: Fischer, Kathryn, Nguyen, Kimberly, LiWang, Patricia J.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7187567/
https://ncbi.nlm.nih.gov/pubmed/31611356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01084-19
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