The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies

Broadly neutralizing HIV antibodies (bnAbs) are typically highly somatically mutated, raising doubts as to whether they can be elicited by vaccination. We used 454 sequencing and designed a novel phylogenetic method to model lineage evolution of the bnAbs PGT121–134 and found a positive correlation...

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Main Authors: Sok, Devin, Laserson, Uri, Laserson, Jonathan, Liu, Yi, Vigneault, Francois, Julien, Jean-Philippe, Briney, Bryan, Ramos, Alejandra, Saye, Karen F., Le, Khoa, Mahan, Alison, Wang, Shenshen, Kardar, Mehran, Yaari, Gur, Walker, Laura M., Simen, Birgitte B., St. John, Elizabeth P., Chan-Hui, Po-Ying, Swiderek, Kristine, Kleinstein, Stephen H., Alter, Galit, Seaman, Michael S., Chakraborty, Arup K., Koller, Daphne, Wilson, Ian A., Church, George M., Burton, Dennis R., Poignard, Pascal
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836729/
https://ncbi.nlm.nih.gov/pubmed/24278016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003754
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