Coformulation of Broadly Neutralizing Antibodies 3BNC117 and PGT121: Analytical Challenges During Preformulation Characterization and Storage Stability Studies

In this study, we investigated analytical challenges associated with the formulation of 2 anti-HIV broadly neutralizing antibodies (bnAbs), 3BNC117 and PGT121, both separately at 100 mg/mL and together at 50 mg/mL each. The bnAb formulations were characterized for relative solubility and conformatio...

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Detalhes bibliográficos
Publicado no:J Pharm Sci
Main Authors: Patel, Ashaben, Gupta, Vineet, Hickey, John, Nightlinger, Nancy S., Rogers, Richard S., Siska, Christine, Joshi, Sangeeta B., Seaman, Michael S., Volkin, David B., Kerwin, Bruce A.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6269598/
https://ncbi.nlm.nih.gov/pubmed/30176252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2018.08.012
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