Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC inhibitors using fragment-based methods and structure-based design

The frequent deregulation of MYC and its elevated expression via multiple mechanisms drives cells to a tumorigenic state. Indeed, MYC is overexpressed in up to ~50% of human cancers and is considered a highly validated anticancer target. Recently, we discovered that WDR5 binds to MYC and is a critic...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Chacón Simon, Selena, Wang, Feng, Thomas, Lance R., Phan, Jason, Zhao, Bin, Olejniczak, Edward T., Macdonald, Jonathan D., Shaw, J. Grace, Schlund, Caden, Payne, William, Creighton, Joy, Stauffer, Shaun R., Waterson, Alex G., Tansey, William P., Fesik, Stephen W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7187413/
https://ncbi.nlm.nih.gov/pubmed/32223236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00224
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