ORCA/LRWD1 Regulates Homologous Recombination at ALT-Telomeres by Modulating Heterochromatin Organization

Telomeres are maintained by telomerase or in a subset of cancer cells by a homologous recombination (HR)-based mechanism, Alternative Lengthening of Telomeres (ALT). The mechanisms regulating telomere-homeostasis in ALT cells remain unclear. We report that a replication initiator protein, Origin Rec...

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Publicat a:iScience
Autors principals: Hsu, Rosaline Y.C., Lin, Yo-Chuen, Redon, Christophe, Sun, Qinyu, Singh, Deepak K., Wang, Yating, Aggarwal, Vasudha, Mitra, Jaba, Matur, Abhijith, Moriarity, Branden, Ha, Taekjip, Aladjem, Mirit I., Prasanth, Kannanganattu V., Prasanth, Supriya G.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7186530/
https://ncbi.nlm.nih.gov/pubmed/32344376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101038
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