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Cell-state dynamics and therapeutic resistance in melanoma from the perspective of MITF and IFNγ pathways

Targeted therapy and immunotherapy have greatly improved the prognosis of patients with metastatic melanoma, but resistance to these therapeutic modalities limits the percentage of patients with long-lasting responses. Accumulating evidence indicates that a persisting subpopulation of melanoma cells...

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Pubblicato in:Nat Rev Clin Oncol
Autori principali: Bai, Xue, Fisher, David E., Flaherty, Keith T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7185899/
https://ncbi.nlm.nih.gov/pubmed/30967646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41571-019-0204-6
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