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A concise, enantioselective approach for the synthesis of yohimbine alkaloids

We report a concise, enantioselective synthesis of the yohimbine alkaloids (−)-rauwolscine and (−)-alloyohimbane. The key transformation involves a highly enantio- and diastereoselective NHC-catalyzed dimerization and an amidation/N-acyliminium ion cyclization sequence to furnish four of the five re...

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Foilsithe in:J Am Chem Soc
Main Authors: Miller, Eric R., Hovey, M. Todd, Scheidt, Karl A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7185878/
https://ncbi.nlm.nih.gov/pubmed/31951394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b12319
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