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Concise and Enantioselective Total Synthesis of (−)-Mehranine, (−)-Methylenebismehranine, and Related Aspidosperma Alkaloids()

We report an efficient and highly stereoselective synthetic strategy for the synthesis of aspidosperma alkaloids based on the transannular cyclization of a chiral lactam precursor. Three new stereocenters are formed in this key step with excellent level of diastereoselection due to the conformationa...

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Détails bibliographiques
Publié dans:Angew Chem Int Ed Engl
Auteurs principaux: Mewald, Marius, Medley, Jonathan William, Movassaghi, Mohammad
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4240000/
https://ncbi.nlm.nih.gov/pubmed/25196158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201405609
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