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Quantifying tetrahedral adduct formation and stabilization in the cysteine and the serine proteases

Two new papain inhibitors have been synthesized where the terminal α-carboxyl groups of Z-Phe-Ala-COOH and Ac-Phe-Gly-COOH have been replaced by a proton to give Z-Phe-Ala-H and Ac-Phe-Gly-H. We show that for papain, replacing the terminal carboxylate group of a peptide inhibitor with a hydrogen ato...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta Proteins Proteom
Main Authors: Cleary, Jennifer A., Doherty, William, Evans, Paul, Malthouse, J. Paul G.
Formato: Artigo
Idioma:Inglês
Publicado em: Published by Elsevier B.V. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7185411/
https://ncbi.nlm.nih.gov/pubmed/26169698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2015.07.006
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