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A new lysine derived glyoxal inhibitor of trypsin, its properties and utilization for studying the stabilization of tetrahedral adducts by trypsin
New trypsin inhibitors Z-Lys-COCHO and Z-Lys-H have been synthesised. K(i) values for Z-Lys-COCHO, Z-Lys-COOH, Z-Lys-H and Z-Arg-COOH have been determined. The glyoxal group (–COCHO) of Z-Lys-COCHO increases binding ~300 fold compared to Z-Lys-H. The α-carboxylate of Z-Lys-COOH has no significant ef...
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| Publicado no: | Biochem Biophys Rep |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5600458/ https://ncbi.nlm.nih.gov/pubmed/28955834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2015.12.015 |
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