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Protein modification by acrolein: Formation and stability of cysteine adducts

The toxicity of the ubiquitous pollutant and endogenous metabolite, acrolein, is due in part to covalent protein modifications. Acrolein reacts readily with protein nucleophiles via Michael addition and Schiff base formation. Potential acrolein targets in protein include the nucleophilic side chains...

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Detalhes bibliográficos
Main Authors: Cai, Jian, Bhatnagar, Aruni, Pierce, William M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929760/
https://ncbi.nlm.nih.gov/pubmed/19231900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx800465m
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