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Protein modification by acrolein: Formation and stability of cysteine adducts
The toxicity of the ubiquitous pollutant and endogenous metabolite, acrolein, is due in part to covalent protein modifications. Acrolein reacts readily with protein nucleophiles via Michael addition and Schiff base formation. Potential acrolein targets in protein include the nucleophilic side chains...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2929760/ https://ncbi.nlm.nih.gov/pubmed/19231900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx800465m |
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