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Protein modification by acrolein: Formation and stability of cysteine adducts

The toxicity of the ubiquitous pollutant and endogenous metabolite, acrolein, is due in part to covalent protein modifications. Acrolein reacts readily with protein nucleophiles via Michael addition and Schiff base formation. Potential acrolein targets in protein include the nucleophilic side chains...

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Bibliografski detalji
Glavni autori: Cai, Jian, Bhatnagar, Aruni, Pierce, William M.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929760/
https://ncbi.nlm.nih.gov/pubmed/19231900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx800465m
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